Clinical Investigation Of Mitochondrial Biogenesis In Multiple Myeloma

Background: Many cancers including multiple myeloma (MM) retain more cytosolic iron to promote tumor cell growth and drug resistance. Higher cytosolic iron promotes oxidative damages due to its interaction with reactive oxygen species generated by mitochondria. Though many other pre-clinical studies for targeting mitochondria have been reported in MM, it remains unclear whether the mitochondrial biogenesis is beneficial or detrimental for tumor cells is not clear. A better understanding of the genetic makeup of mitochondria in MM cells is required if we want to use mitochondria as specific targets.