Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery

•Metabolism (anabolism and catabolism) of amyloid-βeta (Aβ-peptide) occurred both in periphery and brain.•An imbalance in metabolism of Aβ-peptide results in peripheral and central abnormalities.•Different pathways involved in Aβ-peptide metabolism communicate and interlinked brain and periphery.•AD pathogenesis is closely associated with several peripheral abnormalities.•Peripheral understanding of Aβ-peptide in AD pathology might leads towards new treatments and diagnostic biomarkers.