PD29-12 AGE-RELATED CHANGES IN REPRODUCTIVE FUNCTION OF MEN WITH AZOOSPERMIA SUGGEST NONOBSTRUCTIVE AZOOSPERMIA IS A PROGRESSIVE DISEASE

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD29)1 Sep 2021PD29-12 AGE-RELATED CHANGES IN REPRODUCTIVE FUNCTION OF MEN WITH AZOOSPERMIA SUGGEST NONOBSTRUCTIVE AZOOSPERMIA IS A PROGRESSIVE DISEASE Shoichiro Iwatsuki, Yukihiro Umemoto, Tomoki Takeda, Satoshi Nozaki, Yasue Kubota, Hiroki Kubota, Hiroyuki Kamiya, and Takahiro Yasui Shoichiro IwatsukiShoichiro Iwatsuki More articles by this author , Yukihiro UmemotoYukihiro Umemoto More articles by this author , Tomoki TakedaTomoki Takeda More articles by this author , Satoshi NozakiSatoshi Nozaki More articles by this author , Yasue KubotaYasue Kubota More articles by this author , Hiroki KubotaHiroki Kubota More articles by this author , Hiroyuki KamiyaHiroyuki Kamiya More articles by this author , and Takahiro YasuiTakahiro Yasui More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002030.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Late marriage is a serious social issue in Japan. We reported an increasing trend in the age of men with azoospermia in accordance with late marriage (AUA annual meeting 2020). There is a concern that aging in men with azoospermia has a harmful effect on the reproductive system. However, age-related changes in the reproductive function of such men have not been assessed. Here, we evaluated the relationship between age and testicular volume or reproductive hormone levels in Japanese men with azoospermia. METHODS: This study included 109 men with obstructive azoospermia (OA) and 335 with nonobstructive azoospermia (NOA) who underwent surgical sperm extraction at our institution. Patients with chromosomal aberrancy were excluded. A correlation between patient age and testicular volume, serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), or total testosterone (TT) were assessed. Furthermore, the correlation between age and serum anti-Mullerian hormone (AMH) in 36 and 123 men with OA and NOA, respectively, was also assessed. For statistical analysis, Pearson’s product moment correlation coefficient was used. RESULTS: Serum FSH in men with OA gradually increased with age; however, that in men with NOA was significantly elevated and had no correlation with age. In men with NOA, testicular volume and serum AMH levels significantly decreased with age, but not in men with OA (p<0.05). Serum LH and TT had no significant correlation with age in both groups (Figure). CONCLUSIONS: This is the first report to assess age-related changes in testicular volume and reproductive hormone levels in men with azoospermia. Atrophy of the testis and decreased AMH level indicate degeneration of the seminiferous tubules and Sertoli cell function, respectively. Based on our results, it is suggested that NOA is a progressive disease. Early planning of testicular sperm extraction is necessary for men with NOA. Source of Funding: none © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e531-e531 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shoichiro Iwatsuki More articles by this author Yukihiro Umemoto More articles by this author Tomoki Takeda More articles by this author Satoshi Nozaki More articles by this author Yasue Kubota More articles by this author Hiroki Kubota More articles by this author Hiroyuki Kamiya More articles by this author Takahiro Yasui More articles by this author Expand All Advertisement Loading ...