Insights on Rosetting Phenomenon in Plasmodium vivax Malaria

Purpose of Review Information about rosettes in Plasmodium vivax infection is scarce. However, the understanding of this phenomenon is important for elucidating the pathobiology of Plasmodium spp. This review summarizes the advances in the knowledge of rosetting phenomenon in P. vivax malaria. Recent Findings In vitro and ex vivo studies seek to shed light on some aspects of rosetting in vivax malaria. The major efforts are to determine the purpose of this phenomenon and the elements involved in rosetting. Recent data reveal a receptor and suggest that specific components are involved in rosetting. Moreover, there is strong evidence supporting the role of rosettes as an immune evasion strategy. Summary Although there are many unknown aspects behind rosetting, recent findings have contributed to elucidating rosette formation mechanisms and have clarified its role and biological hallmarks. These findings reinforce that rosetting is important and understanding the underlying biology may help develop new strategies for malaria control.