Ph And H2s Dual-Responsive Magnetic Metal-Organic Frameworks For Controlling The Release Of 5-Fluorouracil
ACS APPLIED BIO MATERIALS(2021)
摘要
Along with the increasing cancer incidence, developing suitable drug delivery systems (DDSs) is becoming urgent to control drug release and further enhance therapeutic efficiency. Herein, a Fe-Zn bimetallic MOF-derived ferromagnetic nanomaterial was synthesized by a one-step method. The successful preparation of ferromagnetic Fe-ZIF-8 was verified by scanning electron microscopy, powder X-ray diffraction, Brunauer-Emmett-Teller, X-ray photoelectron spectroscopy, and physical property measurement system characterizations. Furthermore, the release behaviors of 5-FU from the ferromagnetic carrier were investigated in a simulative cancer microenvironment of PBS buffer solution (PBS = phosphate-buffered saline, pH = 5.8) and NaHS solution. The vehide in PBS solution of pH = 5.8 and NaHS solution of 500 mu M can rapidly release 5-FU with the cumulative release percentages of 68 and 36%, respectively, within two hundred minutes. The release mechanism in the weak acid environment can be mainly attributed to the decomposition of the Fe-ZIF-8. However, the strong interaction between Zn and Fe atoms in Fe-ZIF-8 and the S atom in H2S plays an important role in the release process in the simulated H2S cancer microenvironment. The investigation of release kinetic models indicates that the 5-FU release in the PBS solutions and NaHS solution of 500 mu M can be accurately fitted by a second-degree polynomial model and first-order model, respectively. In addition, the decomposition products, zinc, iron, and 2-MeIM, are endogenous and show low toxicity values [LD50 (Zn) = 0.35 g.kg(-1), LD50 (Fe) = 30 g.kg(-1), and LD50 (2-MeIM) = 1.4 g.kg(-1)]. Therefore, the low-toxicity, pH and H2S dual-stimuli-responsive, and ferromagnetic nature make the obtained Fe-ZIF-8 an ideal candidate in the field of bioactive molecule delivery.
更多查看译文
关键词
ferromagnetic nanomaterial, pH and H2S dual-stimuli-responsive, rapid release, target release, Fe-Zn bimetallic MOF, low toxicity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要