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In Vivo Bioactivities of Food Protein-Derived Peptides – a Current Review

Current Opinion in Food Science(2021)SCI 2区

Univ Fed Fronteira Sul UFFS | Univ Fed Rio Grande do Sul UFRGS

Cited 78|Views15
Abstract
A great diversity of biological activities has been attributed to peptides. Despite food proteins are essentially considered as sources of dietary amino acids, bioactive peptides can be released during gastrointestinal transit, food fermentation, food maturation, and through enzymatic bioprocessing in vitro. Specific bioactive peptide databases integrated with predictive proteolytic cleavage of proteins are valuable tools allowing a rapid in silico screening of the bioactive potential of dietary proteins. The range of bioactivities generated by hydrolysis of food proteins include antioxidant, antihypertensive, antidiabetic, immunomodulatory, anticancer, and opioid activities. Some of these bioactivities have been also confirmed in vivo, reinforcing their physiological relevance. This review presents a current perspective on the production and main biological activities of peptides derived from food proteins.
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Bioactive Peptides,Protein Hydrolysates,Food-Derived Peptides,Antioxidant Activity
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要点】:该论文综述了来自食物蛋白的水解肽的体内生物活性,强调了这些生物活性肽在抗氧化、抗高血压、抗糖尿病、免疫调节、抗癌和阿片样活动等方面的潜在应用,并通过体内实验证实了其生理相关性。

方法】:通过整合具有蛋白质水解预测功能的特定生物活性肽数据库,进行快速体外筛选,评估食物蛋白的生物活性潜力。

实验】:论文未详细说明具体的实验过程、使用的数据集名称和结果,因此无法给出相应的概括。但整体上,实验可能包括对食物蛋白的水解产物进行体内功能性评估,以验证其生物活性。