Fumaria Officinalis-Assisted Synthesis Of Manganese Nanoparticles As An Anti-Human Gastric Cancer Agent

Regarding applicative, facile, green chemical research, a bio-inspired approach is being reported for the synthesis of Mn nanoparticles by Fumaria officinalis as a natural reducing/stabilizing and solid support agent without using any toxic and harmful reagent. The MnNPs were synthesized using an aqueous extract of Fumaria officinalis. The formation and morphology of the nanoparticles were evaluated using different techniques including fourier-transform infrared spectroscopy (FTIR), UV-Visible spectroscopy, X-ray diffraction analysis (XRD), scanning electron microscope (SEM), and energy dispersive X-ray analysis (EDX) analysis. The properties of Fumaria officinalis leaf aqueous extract and MnNPs against common human gastric cancer cell lines i.e. KATOIII, NCI-N87, and SNU-16 were studied. The results show the successful formation of MnNPs with a spherical morphology with an average size of 50.05 nm. The viability of malignant human gastric cell line reduced dose-dependently in the presence of Fumaria officinalis leaf aqueous extract and MnNPs. After the clinical study, MnNPs can be utilized as an efficient drug in the treatment of human gastric cancer in humans. (C) 2021 Published by Elsevier B.V. on behalf of King Saud University.