A Rh(II)- or Ag(I)-Catalyzed Formal C-O Bond Insertion of Cyclic Hemiaminal with Aryl Diazoacetate
SYNLETT(2021)
摘要
A mild and facile synthetic method via convergent assembly of two reactive intermediates generated in situ has been developed. This method provides an efficient way to construct six- and seven-membered N-heterocycles containing a biaryl linkage. This reaction features a gem-difunctionalization process of diazo compounds with cyclic hemiaminals, delivering alpha-hydroxyl-beta-amino ester derivatives with a tertiary carbon center through a formal C-O bond-insertion transformation.
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关键词
metal carbene,cyclic hemiaminals,alpha-hydroxyl-beta-amino esters,N -heterocycles,atom economy
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