Anterior Default Mode Network Mediates the Relationship Between Systemic Inflammation and Cognition in Idiopathic Psychosis

Paulo Lizano,Sarah Keedy,Shashwath Meda,Kristian Hill,Adam Lee,Olivia Lutz,Leah Rubin,Carol Tamminga,Brett Clementz,Godfrey Pearlson,Elliot Gershon,John A. Sweeney,Matcheri Keshavan,Jeffrey Bishop

Biological psychiatry（2021）

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摘要

Default mode network (DMN) dysfunction exists in psychosis and is associated with both systemic inflammation and impaired cognition. Here we examined whether inflammatory-based cognitive alterations in psychosis may be partially explained by DMN alterations.

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Neurocognition,fMRI,Inflammation

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