Novel benzo[4,5]thiazolo[2,3-C][1,2,4]triazoles: Design, synthesis, anticancer evaluation, kinase profiling and molecular docking study

•Some benzo[4,5]thiazolo[2,3-c][1,2,4]triazole-based derivatives were synthesized.•The cytotoxicity of compounds 8-12 was investigated against three cancer cell lines.•Compound 12 was the most active against cancer cell growth (IC50 = 2.40 - 3.53 μM).•Compound 12 caused 3-4 times induction in caspase 3/7 in A549 cells.•Compound 12 displayed moderate inhibitory activity against EGFR and LCK kinases.•Docking study of compounds 8-12 into EGFR/LCK kinases was performed.