Co(II), Ni(II), and Cu(II) metal complexes based on thiourea ligand: synthesis, characterization, thermal behaviors, anticancer, and antioxidant activities

In this study, N-(1,1 '-biphenyl)-2-chlorobenzoylthiourea (HL) and its metal complexes were prepared and their structural characterization was made using elemental analysis, FT-IR, (HNMR)-H-1, HR-MS, single crystal XRD techniques, and TG/DTA analysis. The crystal structure of HL was investigated using single crystal X-ray diffraction and was observed to crystallize in the monoclinic crystal system with P 1 21/c 1 space group, Z = 4, a = 7.3291(4) angstrom, b = 20.7880(10) angstrom, c = 12.0074(6) angstrom. The structures of the complexes and the molecular orbitals of HL were optimized at B97D/TZVP level. Investigation of the thermal and electrochemical behaviors of the Co(II), Ni(II), and Cu(II) complexes were found to be thermally stable up to 165, 185, and 122 degrees C, respectively. Cell viability test MTT was made to determine anticancer activities against MCF-7 breast cancer cells and 2,2-diphenyl-1-picrilhydrazyl and 2,2 '-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid analysis for the antioxidant activity. The IC50 values against MCF-7 cells and was found to be in the range 24.3-49.2 mu M.