Design, synthesis, anticancer activity and molecular docking analysis of novel dinitrophenylpyrazole bearing 1,2,3-triazoles
Journal of Molecular Structure(2021)
摘要
•Novel dinitrophenylpyrazole bearing 1,2,3-triazol molecular hybrids were reported.•Its structure elucidation was established via different spectroscopic techniques.•Synthesized compounds were evaluated anti-cancer activity (in vitro) against three human cell lines.•Compounds 9e, 9f, and 9 h showed the high potency growth inhibitory activity against the HeLa cell line.•Binding interaction were also validated with molecular docking studies.
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关键词
Synthesis,Pyrazoles,Triazoles,Cytotoxic activity,HeLa,Docking analysis
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