Tgf-Beta Signaling And Microrna Cross-Talk Regulates Abdominal Aortic Aneurysm Progression
CLINICA CHIMICA ACTA(2021)
摘要
Abdominal aortic aneurysms (AAA) are permanent and irreversible local dilatations of the abdominal aortic wall. Recent data indicate that the transforming growth factor-beta (TGF-beta) signaling pathway exerts a protective effect on the development of AAA. Some dysregulated microRNAs (miRNA) also appear involved in the expansion of AAA and miRNA-based therapeutics have been shown to effectively inhibit this process. New evidence has revealed that TGF-beta signaling and miRNA interaction may of physiologic and pathophysiologic significance including the progression of AAA. As such, miRNA that regulate TGF-beta signaling may hold promise as potential therapeutic targets. This review explores potential crosstalk between TGF-beta signaling and miRNA in AAA in order improve our understanding of this pathology and explore development of potential therapeutic targets.
更多查看译文
关键词
Abdominal aortic aneurysms, TGF-beta signaling pathway, MicroRNA
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要