Electrochemical Methods For The Detection Of Poly(Adp-Ribose) Polymerase-1

Poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in DNA repair and apoptosis. The enzyme has been regarded as the biomarker for many diseases including cancer. Therefore, simple, sensitive and rapid detection of PARP-1 is of great significance for early diagnosis and medical treatment. Electrochemistry-based biosensors have attracted much attention due to their low cost, simple operation, rapid response and high sensitivity. In this work, we summarized the electrochemical strategies for determining PARP-1 activity and screening the potential inhibitors.