737P Phase II Study of IV Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous Primary Peritoneal, Fallopian Tube or Ovarian Cancer (VIP)

N. Y. L. Ngoi,T. Z. Tan,K. T. Kuay, A. C. Y. Tan, J. Y. Lee, M. Y. Pang,K. W. Tham,J. Chan, W. L. Wong,W. Y. Chay, D. Anne,M. Friedlander,S. Varma,T. Meniawy,G. Au-Yeung,C. Scott,L. Mileshkin,D. Bowtell,R. Y-J. Huang,D. S. P. Tan

Annals of oncology（2021）

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摘要

The Australian Ovarian Cancer Study identified 4 distinct molecular subtypes of high-grade serous ovarian cancer (HGSOC). C5 subtype is linked to poor prognosis and stemness behavior. We have previously described dependency of C5 HGSOC on genes related to microtubule dynamics. In vitro and vivo studies have shown sensitivity of C5 subtype HGSOC cell lines and patient-derived xenografts to tubulin-depolymerizing vinca alkaloids such as vinorelbine.

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