Design, Spectral Characteristics, And Possibilities For Practical Application Of Bodipy Fl-Labeled Monoterpenoid

This article describes the design and biological properties of a BODIPY FL-labeled monoterpenoid BF2-meso-(4-((1 '' R)-6 '',6 ''-dimethylbicyclo[3.1.1]hept-2 ''-ene-2 '')yl-methoxycar- bonylpropyl)-3,3',5,5'-tetramethyl-2,2'-dipyrromethene conjugate (BODIPYmyrt). The fluorophore was characterized using X-ray, NMR, MS, and UV/vis spectroscopy. The conjugate exhibits a high quantum yield (to similar to 100%) in the region 515-518 nm. BODIPYmyrt effectively penetrates the membranes of the bacterial and fungal cells and therefore can be used to examine the features of a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi as well. Moreover, BODIPYmyrt exhibits a moderate tropism to the subcellular structures in mammalian cells (e.g., mitochondria), thereby providing an attractive scaffold for fluorophores to examine these particular organelles.