The Increasing Incidence Of Uterine Serous Cancers In The Elderly And Black Women: What Molecular Markers Can Guide Novel Treatment Approaches For These Patients?

Objectives: To evaluate rare histologic subtypes of uterine cancer in women older than 70 years of age using four large national databases. Methods: Incidence rates were estimated in elderly women diagnosed at age 70+ years old with uterine cancer between 2001 and 2016 from the United States Cancer Statistics (USCS) program after correcting for hysterectomy and pregnancy prevalence from the Behavioral Risk Factor Surveillance System. SEER*Stat and Joinpoint regression were used to calculate the incidence rate (per 100,000) and average annual percent change (AAPC). Data from National Cancer Institute Genomic Data Commons Data Portal including The Cancer Genome Atlas Program (TCGA) were obtained to evaluate genomic features that vary between racial groups. Results: Conclusions: There is a significant increase in serous uterine cancer in elderly black patients at an annual rate of 7% that is projected to surpass endometrioid adenocarcinoma within 10 years. Further research must be conducted into potential treatments such as targetable therapies to provide clinical benefit for these patients with overall poorer prognosis. To evaluate rare histologic subtypes of uterine cancer in women older than 70 years of age using four large national databases. Incidence rates were estimated in elderly women diagnosed at age 70+ years old with uterine cancer between 2001 and 2016 from the United States Cancer Statistics (USCS) program after correcting for hysterectomy and pregnancy prevalence from the Behavioral Risk Factor Surveillance System. SEER*Stat and Joinpoint regression were used to calculate the incidence rate (per 100,000) and average annual percent change (AAPC). Data from National Cancer Institute Genomic Data Commons Data Portal including The Cancer Genome Atlas Program (TCGA) were obtained to evaluate genomic features that vary between racial groups. There is a significant increase in serous uterine cancer in elderly black patients at an annual rate of 7% that is projected to surpass endometrioid adenocarcinoma within 10 years. Further research must be conducted into potential treatments such as targetable therapies to provide clinical benefit for these patients with overall poorer prognosis.