Synthesis Of Bisindolylmethane, Bispyrrolylmethane, And Indolylpyrrolylmethane Derivatives Via Reductive Heteroarylation

An efficient and general reductive heteroarylation approach toward the synthesis of bisindolylmethane, bispyrrolylmethane, and indolylpyrrolylmethane derivatives has been developed. Thus, treatment of acylpyrrole or acylindole derivatives with indoles or pyrroles in the presence of a combination of sodium borohydride and acetic acid resulted in the formation of the title compounds in moderate to excellent isolated yields. (c) 2021 Elsevier Ltd. All rights reserved.