A Study Of Risk Factors Of Gastroesophageal Reflux Complicated With Pulmonary Infections In Neonates, Characteristics Of Pathogenic Bacteria And Prevention Strategies

Objective: This study aimed to analyze the risk factors of gastroesophageal reflux complicated with pulmonary infections and the characteristics of pathogenic bacteria, and to propose prevention strategies. Methods: A total of 40 patients admitted and definitely diagnosed with gastroesophageal reflux complicated with pulmonary infections in Gansu Provincial Maternity and Child-care Hospital from January 2017 to November 2017 were retrospectively analyzed. Univariate and multivariate logistic analyses were conducted for the evaluation of premature delivery, polyembryony, birth asphyxia and rescue history, birth weight, hyperglycemia, esophageal hiatal hernia and esophageal peristaltic dysfunction. The corresponding intervention measures were proposed, and the types of pathogenic bacteria of pulmonary infections were counted. Results: Premature delivery, birth asphyxia history, birth rescue history, postnatal hyperglycemia, definite esophageal hiatal hernia and esophageal peristaltic dysfunction were independent risk factors for neonatal gastroesophageal reflux complicated with pulmonary infections. Gramnegative (G(-)) bacteria were sensitive to cefepime and ceftazidime, while Gram-positive (G(+)) bacteria were sensitive to ampicillin and cefepime. Conclusion: Our data demonstrate that premature delivery, presence of birth asphyxia and rescue history, hyperglycemia after birth, definite esophageal hiatal hernia and peristaltic dysfunction are independent risk factors for neonatal gastroesophageal reflux complicated with pulmonary infections. G(+) bacteria are the dominant pathogens, suggesting the necessity of cefepime in empirical treatment.