High Failure-Free Survival after Unrelated Donor Peripheral Blood Stem Cell Transplantation in Pediatric Severe Aplastic Anemia

•The effect of HLA matched and partially mismatched unrelated donor peripheral blood stem cell transplantation (PBSCT) on outcomes in pediatric severe aplastic anemia were analyzed.•Higher stem cell doses were infused in PBSCT than in bone marrow transplantation.•HLA partially mismatched PBSCT decreased the incidence of secondary graft failure.•HLA disparity and PBSCT did not increase the rate of grade III-IV acute graft-versus-host disease (GVHD) and moderate to severe chronic GVHD.•PBSCT from unrelated donors showed favorable survival outcomes in terms of a superior failure-free survival, comparable GVHD-free and failure-free survival and overall survival.