Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways

Tahmina Yasmin,Md Mizanur Rahman,Ferdous Khan,Fariha Kabir,Kamrun Nahar,Shoumen Lasker,Md Didarul Islam,Mohammad Maqsud Hossain,Raquibul Hasan,Sohel Rana,Md Ashraful Alam

Biochemistry and Biophysics Reports（2021）

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摘要

•High fat diet in rats developed glucose intolerance and oxidative stress in liver.•Metformin restored antioxidant genes expression in liver of HFD fed rats.•Metformin also inhibited the inflammatory genes expression and fibrosis in liver.•Moreover, metformin treatment may ameliorate fatty liver in HFD fed rats.

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关键词

Inflammation,Lipid peroxidation,Metformin,Non-alcoholic fatty liver disease,Obesity

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