A Physical perspective to understand the mechanism of myelin development

In this study, a hypothesis, which conjectures that an E-field modulates the myelin development, is proposed to establish a new theoretical framework for the study of myelin. This E-field consists of components from three different origins: the resting potential, the action potential, and the dipole potential. Each of them has its changing trend with the axonal caliber and the number of myelin lamellae. With detailed analyses of each component, a series of observed unique phenomena of myelin development, such as radial sorting and g-ratio, can be explained. Furthermore, this theory reveals the physical factors modulating the myelination process and builds connections between neural activities and neural development. Finally, a possible experiment is proposed to validate the role of E-field in the myelination process.