Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy

Cynthia L. Bowes,Vivek Naranbhai,Kerri J. St. Denis,Evan C. Lam,Brittany Bertaux,Florence K. Keane,Melin J. Khandekar,Alejandro B. Balazs,John A. Iafrate,Justin F. Gainor,Henning Willers

Radiotherapy and Oncology（2022）

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摘要

The immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy is unknown. This prospective cohort study demonstrates that anti-SARS-CoV-2 spike antibody and neutralization titers are reduced in a subset of thoracic radiotherapy patients, possibly due to immunosuppressive conditions. Antibody testing may be useful to identify candidates for additional vaccine doses.

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关键词

SARS-CoV-2,mRNA vaccine,COVID-19,Lung cancer,Radiotherapy,Immunogenicity

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