Objective:
The feasibility of conducting
in vivo
non-localized
31
P Magnetic Resonance Spectroscopy (MRS) with a 1.0T extremity scanner and the potential to increase accessibility of this important diagnostic tool for low cost applications is revisited.
Methods:
This work presents a custom transmit-only quadrature birdcage, four-element receive coil array, and spectrometer interfaced to a commercial ONI 1.0T magnet for enabling multi-channel, non-
1
H frequency capabilities. A custom, magnetic resonance compatible plantar flexion-extension exercise device was also developed to enable exercise protocols. The coils were assessed with bench measurements and
31
P phantom studies before an
in vivo
demonstration.
Results:
In pulse and acquire spectroscopy of a phantom, the array was found to improve the signal-to-noise ratio (SNR) by a factor of 1.31 and reduce the linewidth by 13.9% when compared to a large loop coil of the same overall size.
In vivo
testing results show that two averages and a four second repetition time for a temporal resolution of eight seconds was sufficient to obtain phosphocreatine recovery values and baseline pH levels aligned with expected literature values.
Conclusion:
Initial
in vivo
human skeletal muscle
31
P MRS allowed successful monitoring of metabolic changes during an 18-minute exercise protocol.
Significance:
Adding an array coil and multinuclear capability to a commercial low-cost 1.0T extremity scanner enabled the observation of characteristic
31
P metabolic information, such as the phosphocreatinerecovery rate and underlying baseline pH.
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关键词
Extremities,Feasibility Studies,Humans,Magnetic Resonance Imaging,Magnetic Resonance Spectroscopy,Phosphocreatine,Signal-To-Noise Ratio
