Detoxifying chemotherapy with genetics-guided stem cell modeling: A personalized affair

Doxorubicin chemotherapy causes cardiotoxicity in some patients and spares others. In this issue of Cell Stem Cell, Magdy et al. (2021) use genome-edited iPSCs to establish a common RARG coding variant as a causal risk factor, pointing to a pharmacogenomic application and to RARG-targeting treatments to protect patients from cardiotoxicity.