Induced Polyspecificity of Human Secretory Immunoglobulin A Antibodies: Is It Possible to Improve Their Ability to Bind Pathogens?

Ekaterina N Gorshkova,Shina Pashova, Ekaterina A Vasilenko, Tatiana S Tchurina, Elizaveta A Razzorenova, Olga V Starkina,Petya Dimitrova,Anastas Pashov,Tchavdar Lubenov Vassilev

Pharmacology(2022)

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摘要
Thus, it was shown that all investigated treatments can alter to some degree the antigen-binding of secretory IgA, but acidic pH has the most potentially beneficial effect by increasing binding to a largest number of common pathogens' antigens.
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关键词
Human secretory IgA,Natural and induced polyspecificity,Pathogen epitopes,Peptide microarray analysis
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