Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in doxorubicin-induced apoptosis in rat cardiac myocytes

•Oxidative stress plays a critical role in doxorubicin-induced apoptosis of cells.•EIF5A is secreted from cells in response to oxidative stress and induces apoptosis.•Doxorubicin-induced apoptosis of cardiac myocytes is partially mediated by ORAIP.•ORAIP can be a sensitive biomarker for doxorubicin-induced apoptosis.•ORAIP may be a possible therapeutic target for doxorubicin-induced apoptosis.