Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in doxorubicin-induced apoptosis in rat cardiac myocytes

International Journal of Cardiology(2022)

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摘要
•Oxidative stress plays a critical role in doxorubicin-induced apoptosis of cells.•EIF5A is secreted from cells in response to oxidative stress and induces apoptosis.•Doxorubicin-induced apoptosis of cardiac myocytes is partially mediated by ORAIP.•ORAIP can be a sensitive biomarker for doxorubicin-induced apoptosis.•ORAIP may be a possible therapeutic target for doxorubicin-induced apoptosis.
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关键词
eIF5A,I/R,ORAIP,ROS
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