Efficient and Accurate Computational Model of Neuron with Spike Frequency Adaptation.

Simplified models of neurons are widely used in computational investigations of large networks. One of the most important performance metrics of simplified models is their accuracy in reproducing action potential (spike) timing. In this article, we developed a simple, computationally efficient neuron model by modifying the adaptive exponential integrate and fire (AdEx) model [1] with sigmoid afterhyperpolarization current (Sigmoid AHP). Our model can precisely match the spike times and spike frequency adaptation of cortical pyramidal neurons. The accuracy was similar to a more complex two compartment biophysically realistic model of the same neurons. This work provides a simplified neuronal model with improved spike timing accuracy for use in modeling of large neural networks.Clinical Relevance- Accurate and computationally efficient single neuron model will enable large network modeling of brain regions involved in neurological and psychiatric disorders and may lead to a better understanding of the disorder mechanisms.