Frequency distribution of HCV resistance-associated variants in infected patients treated with direct-acting antivirals

Bianca Catarina Azeredo Cabral,Juliene Antonio Ramos, Amanda Laryssa de Melo Silveira, Érica Ramos dos Santos Nascimento, Selma Baía Ferreira,Henrique Sérgio Moraes Coelho,Rodrigo Soares Moura-Neto,Cristiane Alves Villela-Nogueira,Luísa Hoffmann,Rosane Silva

International Journal of Infectious Diseases（2022）

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摘要

•Resistance-associated variants (RAVs) were evaluated by massively parallel sequencing.•Non-synonymous substitutions were detected for genotypes 1 and 3 at baseline.•Higher non-synonymous substitutions were found in hepatitis C virus (HCV) 3a NS3/NS5a regions.•RAVs were found in responders and non-responders.•RAVs at baseline did not interfere with the success of direct-acting antiviral therapy.

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关键词

Hepatitis C,Massively parallel sequencing,RAVs,Treatment response

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