Evaluation of distributional homogeneity of pharmaceutical formulation using laser direct infrared imaging

International Journal of Pharmaceutics(2022)

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摘要
•Evaluation of the homogeneity of a pharmaceutical formulation with hyperspectral imaging.•Raman imaging has a high spectral specificity but long acquisition times.•Infrared quantum cascade laser imaging (LDIR) may provide a valuable alternative.•LDIR achieved mostly similar results as Raman imaging in 30 times less time.
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关键词
Laser direct infrared imaging,Raman imaging,Homogeneity,Vibrational spectroscopy,Distributional Homogeneity Index (DHI),Pharmaceutical formulations development
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