The N6-methyladenosine reader protein YTHDC2 promotes gastric cancer progression via enhancing YAP mRNA translation

Wei Yuan,Shiqiang Chen,Bo Li,Xiaoyu Han,Bo Meng,Yongping Zou,Shunwu Chang

Translational Oncology（2022）

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摘要

•YTHDC2 is significantly upregulated in human GC tissues, which is linked to poor prognosis.•Knockout of YTHDC2 inhibits GC cell proliferation, migration and invasion.•YTHDC2 enhances YAP translation in a m6A-dependent manner.•YAP transcriptionally activates YTHDC2.•Knockout of YTHDC2 inhibits GC tumor growth and metastasis in vivo.

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关键词

m6A,YTHDC2,YAP,Translation regulator,Biomarker

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