Hidradenitis Suppurativa in Acute Myeloid Leukemia: Review of Disease Course and Management.

Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by recurrent nodules and abscesses in apocrine gland-bearing regions.1 Neutrophils are postulated to be pathogenic drivers in HS pathogenesis, since neutrophilia is often seen in patients with severe disease.1-3 However, antineutrophil agents, such as dapsone, are generally ineffective in severe disease, suggesting that neutrophils may be a secondary contributor.4 In order to further elucidate the role of neutrophils in HS pathogenesis, we performed a retrospective review of patients with HS and acute myeloid leukemia (AML) to observe the effect of neutrophil depletion during induction chemotherapy on HS.