Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension

•Ang-(1–12) is an endogenous Ang II-forming substrate that contributes to the maintenance of arterial pressure.•Immunoneutralization of human Ang-(1–12) employing a selective mAb blocks the vasoconstrictor activity of this Ang II-generating substrate.•The h-Ang-(1–12) mAb has antihypertensive actions when given into the circulation of transgenic rats expressing the human AGT gene.•Ang-(1–12) mAbs may be facilitate long-term therapeutic control of blood pressure alone or combined with other antihypertensive medications.