Toxicity assessment of synthetic chalcones with antileishmanial potential in BALB/c mice.

Karina Cancino,Inés Castro, Carlos Yauri,Valérie Jullian,Jorge Arévalo,Michel Sauvain,Vanessa Adaui,Denis Castillo

Revista peruana de medicina experimental y salud publica（2021）

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摘要

The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.

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