DISSECTION OF BONE MARROW MICROENVIRONMENT BY SINGLE CELL RNA SEQUENCING IN WARM AIHA PATIENTS: A PROOF-OF-CONCEPT ANALYSIS

Warm type autoimmune hemolytic anemia (wAIHA) is a rare disease characterized by variable severity and bone marrow (BM) compensation, unpredictable relapses and several complications (i.e. infections and thrombosis). Most therapies are aimed at restoring immune tolerance by targeting various immunologic mechanisms (autoantibody production, reticuloendothelial phagocytosis, and complement activation). BM composition during acute and chronic/relapsing disease phases is still under investigated, and preliminary studies showed that it may predict anemia severity and treatment response.