Hells Promotes Transcription in Lymphoma By Resolving Topological Conflicts and By Preventing DNA Damage

T cell lymphomas (TCLs) are a rare and heterogeneous group of non Hodgkin Lymphoma with aggressive courses and prognoses. TCLs are characterized by genomic instability and massive transcriptional activity that is required to sustain cancer cell proliferation. Indeed, high rate of transcription increases DNA topological tension resulting in accumulation of DNA-RNA hybrid structures called R-Loops, in which the nascent RNA pairs with its DNA-template, favouring structural alterations and DNA-lesions.