Fuzzy multiobjective hierarchical optimization with application to identify antienzymes of colon cancer cells

Feng-Sheng Wang,Tsun-Yu Wang,Wu-Hsiung Wu

Journal of the Taiwan Institute of Chemical Engineers（2022）

引用 5|浏览3

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摘要

•Develop a fuzzy multi-objective hierarchical optimization framework for identifying anticancer targets.•Prove the existence of transformation from a hierarchical optimization problem to a maximizing decision-making problem.•Identify one-target antienzymes and two-target combinations of Sanger cancer cell lines.

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关键词

Evolutionary optimization,Bioprocess systems engineering,Flux balance analysis,Cancer cell metabolism,Metabolic modeling,Drug target discovery

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