Genetically Encoded Fragment-Based Discovery (GE-FBD) from Phage-Displayed Macrocyclic Libraries with Genetically-Encoded Unnatural Pharmacophores

ARUNIKA EKANAYAKE,Lena Sobze,Jihea Youk,Nicholas J. Bennett,Raja Mukherjee,Atul Bhardwaj,Frank Wuest,Ratmir Derda

semanticscholar（2020）

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摘要

Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophoresLate stage functionalization of genetically encoded 1,3-diketone macrocyclic phage libraries by pharmacophores containing hydrazine handles.

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