Establishment of human embryonic stem cell (SKLRMe001-A)carrying Azoospermic factor c (AZFc) deletions

Chuyu Li,Lingbo Cai,Juan Dong,Song Ning,Jing Zhou,Huimin Wu,Yugui Cui,Lianju Qin,Xiaoyu Yang

Stem Cell Research（2022）

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摘要

•Microdeletion of the Y chromosome causes of male infertility.•Azoospermia factor c (AZFc) is the most common deletion.•We generated a human embryonic stem cell (SKLRMe001-A) line with AZFc deletion.•The cells can be used as an in vitro model of AZFc deletion syndrome.

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