Hypervalent Iodine‐Mediated Late‐Stage Peptide and Protein Functionalization

Hypervalent iodine reagents are commonly used for the development of novel transformations. As they are highly reactive and biocompatible, they have been employed more recently for the functionalization of biomolecules. This Minireview discusses the development of hypervalent iodine reagents for the modification of peptides and proteins as well as their application, such as for labeling and peptide stapling.