In silico Study of Marine Algae as Potential Inhibitory Compounds with SARS-CoV-2 Main Protease

Introduction: We perform an in silico study to identify potential antiviral compounds of Algae in inhibiting SARS-CoV-2. Methods: We conducted a literature search for microalgae and macroalgae compounds that had been confirmed as against antiviral effects. Then, docking analysis was done by Molegro Virtual Docker software to test these compounds as the potential for the main protease (Mpro) protein of SARS-CoV2 (ID 6LU7.). Results: Of the 12 screened compounds, 4 compounds (6,6’-Bieckol, Pseudotheonamide C, 8,8’-Bieckol, Dieckol) have been gained more scores in comparison with test standards. Conclusions: The algae compounds can be suggested to utilize against this pandemic viral infection as an inhibitory substance. Copyright © 2020, Focus on Medical Sciences Journal. This is