PP15 Presentation Time: 3:48 PM

Background: Recurrent GBM (rGBM) is a diffuse disease, and local therapy alone does not routinely provide durable local control (LC) or prolong overall survival (OS). Hypothesizing resection (R) plus immediate radiation (RT) may achieve durable LC and secondarily improve OS by permitting time for subsequent potentially effective but biologically slower treatments to have an impact, we prospectively evaluated R combined with a novel brain brachytherapy device utilizing Cs-131 embedded in bioresorbable collagen tiles with the intention of combining R and immediate onset radiation surgically targeted radiation therapy (STaRT).