Detection of Metabolite-Protein Interactions in Complex Biological Samples by High-Resolution Relaxometry: Towards Interactomics by NMR

Ziqing Wang,Veronica Ghini,Pavel Kaderavek,Simone Pisano,Milan Zachrdla,Philippe Pelupessy,Morgan Kazmierczak,Thorsten Marquardsen,Jean-Max Tyburn,Guillaume Bouvignies,Giacomo Parigi,Claudio Luchinat,Fabien Ferrage

semanticscholar（2021）

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摘要

In this manuscript, we introduce an NMR method to investigate the interaction of metabolites and other small molecules with proteins in biological fluids. Our approach, based on high-resolution relaxometry identifies the interaction of small molecules with proteins in blood serum and is used for the quantitative analysis of binding competition in situ.

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