Radiosynthesis and Biological Evaluation of 99m Tc Nitrido-Levetiracetam as a Brain Imaging Agent

99m Tc nitrido-Levetiracetam was prepared using the 99m Tc nitrido core for labeling. The reaction conditions were optimized to get the highest radiochemical purity (98%): substrate amount 2 mg, Sn(II) (reducing agent) amount 50 µg, pH 7, 30 min, ambient temperature. The biodistribution studies revealed high brain uptake of 99m Tc nitride-Levetiracetam, reaching a maximum of 9% ID/g at 30 min post injection (p.i.). The complex deserves further analysis as a candidate brain imaging agent.