Palladium Catalyzed Enantioselective Hayashi-Miyaura Reaction for Pharmaceutically Important 4-Aryl-3,4-Dihydrocoumarins

The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins was successfully established, providing a straightforward asymmetric approach to achieving pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodolo-gy features easily accessible and bench-stable ligands, a wide substrate scope, mild conditions and good accommodation of challenging, electron-withdrawing arylboronic acids.