Plants Utilise Ancient Conserved Peptide Upstream Open Reading Frames as Environmental Sensors
semanticscholar(2021)
摘要
The regulation of protein synthesis plays an important role in growth
and development in all organisms. Upstream open reading frames (uORFs)
are commonly found in eukaryotic mRNA transcripts and typically
attenuate the translation of associated downstream main ORFs (mORFs).
Conserved peptide uORFs (CPuORFs) are a rare subset of uORFs, some of
which have been shown to conditionally regulate translation by ribosome
stalling. Here we identify three Arabidopsis CPuORFs of ancient origin
that regulate translation of any downstream ORF, in response to
agriculturally significant environmental signals: heat stress and water
limitation. We provide evidence that different sequence classes of
CPuORF stall ribosomes during different phases of translation and show
that plant CPuORFs act as environmental sensors that can be utilised as
inducible regulators of translation with broad application.
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关键词
peptide,open reading frames,plants,sensors,environmental
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