MMP-9 Facilitates Hepatitis B Virus Replication through Binding with IFNAR1 to Repress IFN/JAK/STAT Signaling

MMP-9 Facilitates Hepatitis B Virus Replication through Binding with IFNAR1 to 1 Repress IFN/JAK/STAT Signaling 2 3 Junbo Chen, Wei Xu, Yanni Chen, Xueping Xie, Yecheng Zhang, Chunqiang Ma, 4 Qingyu Yang, Yang Han, Chengliang Zhu, Ying Xiong, Kailang Wu, Fang Liu, Yingle 5 Liu,# and Jianguo Wu# 6 State Key Laboratory of Virology and College of Life Sciences, Wuhan University, 7 Wuhan 430072, China 8 9 10 11 Running title: MMP-9 facilitates HBV replication by repressing IFN 12 13 #Address correspondence to Jianguo Wu, jwu@whu.edu.cn or Yingle Liu, 14 mvlwu@whu.edu.cn 15 16 Word count for the abstract: 219 17 Word count for the text: 7,671 18