enzyme RIA : relative isotope abundance RSLC : rapid separation liquid chromatography SILAC : stable isotope labelling by amino acids in cell culture TM : transmembrane WT : wild-type

Impact of cystinosin glycosylation on protein stability by differential dynamic SILAC Nathalie Nevo *, Lucie Thomas *, Cerina Chhuon , Zuzanna Andrzejewska , Joanna Lipecka , François Guillonneau , Anne Bailleux , Aleksander Edelman , Corinne Antignac , Ida Chiara Guerrera 2,6 INSERM U1163, Laboratory of Hereditary Kidney Diseases, Imagine Institute, Paris, France Plateforme Protéomique Paris Descartes Necker, PPN, 3P5-Necker, SFR Necker, US24, 75014 Paris, France The CPN Proteomics Facility – 3P5, Center of Psychiatry and Neuroscience, UMR INSERM 894, 75014 Paris, France Plateforme Protéomique Paris Descartes Cochin, 3P5-Cochin, 75014 Paris, France 5 INSERM U1151, 75015 Paris, France Paris Descartes-Sorbonne Paris Cité University, Paris, France Assistance Publique Hôpitaux de Paris (AP-HP), Department of Genetics, Necker Hospital, Paris, France.