Nitrofurantoin and Fosfomycin for the CRE and MDR uropathogens: are the choices still same?

Antibiotic resistance among bacteria causing common infections is increasing in all regions of the world. It is interesting that pattern of resistance observed varies from hospital to community, large hospital to small hospital, state to state, and even vary from country to country. Emergence of resistance to antibiotics illustrates importance of using evidence-based strategies for treatment. In urinary tract infection (UTI) cases, antibiotic treatment is often started empirically before the results of urine culture and susceptibility testing are available. Hence, it becomes important to regularly monitor the resistance or susceptibility patterns of uropathogens, so that the guidelines for empirical therapy can be improved to include antibiotics with low resistance, aiding clinicians in proper management of UTIs with minimal therapeutic failures. ABSTRACT