1 Distinct systems serology features in children , elderly and COVID patients 1 2

Distinct systems serology features in children, elderly and COVID patients 1 2 Kevin J. Selva*, Carolien E. van de Sandt*, Melissa M. Lemke*, Christina Y. Lee*, Suzanne K. 3 Shoffner*, Brendon Y. Chua, Thi H.O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios 4 Koutsakos, Chinn Yi Wong, David C. Jackson, Katie L. Flanagan, Jane Crowe, Allen C. 5 Cheng, Denise L. Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak 6 Modhiran, Daniel Watterson, Paul Young, Bruce Wines, P. Mark Hogarth, Robyn 7 Esterbauer , Hannah G. Kelly , Hyon-Xhi Tan, Jennifer A. Juno, Adam K. Wheatley, 8 Stephen J. Kent , Kelly B. Arnold, Katherine Kedzierska*, Amy W. Chung* 9 10 * Equally contributed 11 Co-corresponding authors: 12 Amy W Chung 13 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, 14 The University of Melbourne, Victoria 3000, Australia 15 awchung@unimelb.edu.au 16 17 Katherine Kedzierska 18 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, 19 The University of Melbourne, Victoria 3000, Australia 20 kkedz@unimelb.edu.au 21 22 1 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, 23 The University of Melbourne, Victoria, Australia 24 2 Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, 25 University of Amsterdam, Amsterdam, Netherlands 26 Department of Biomedical Engineering, University of Michigan, Michigan, USA 27 Department of Infectious Diseases, Launceston General Hospital, Launceston, Tasmania, Australia; 28 School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia; 29 Department of Immunology and Pathology, Monash University, Commercial Road, Melbourne, 30 Victoria, Australia; 31 School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia. 32 Deepdene Surgery, Deepdene, Victoria, Australia. 33 School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, 34 Australia. 35 Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, Victoria, 36 Australia. 37 . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted May 18, 2020. ; https://doi.org/10.1101/2020.05.11.20098459 doi: medRxiv preprint